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Myosin Va is a class XIV myosin in eukaryotic cells, specifically in humans and other mammals. In mammals, the gene Myo5a encodes the product of this protein.
This class is not found in plants, fungi, or yeast, and in these organisms the myosin Va gene product is encoded by the myosin vb gene.
The myosin Va gene was originally identified in chicken and this gene has been cloned and sequenced in a wide variety of mammalian species.
Myosin Va is a member of class XIV myosins. Class XIV myosins include the following myosins: myosin Va, myosin Vb, Myo5a (formerly MYO5A), Myo5b, Myo6 and Myo7a. Class XIV myosins share several properties. They are monomeric and have two IQ motifs in the head domain and an actin-capping domain. The actin-capping domain of myosin Va and Myo5a are very similar to the actin-capping domain of non-mammalian myosins, suggesting that they may also serve as actin-capping proteins.
Mammalian myosin Va localises to the apical (upper) and basal (lower) surfaces of epithelial cells in the intestine and kidney, respectively. In the intestinal epithelium, the myosin Va distribution is polarised with respect to the apical-basal polarity of the tissue. The polarity of the tissue is
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And if you want to come up with a strategy to deal with it, you need to understand that you can’t win without it. Consider the following scenario. A customer has in-store technology that gives them the ability to provide products and services that they lack in their own departments. For instance, a conventional camera is very much better suited to taking pictures in the in-store environment than in the field, but the customer might not have that expertise. A store needs a photographer who is mobile. Instead of paying that photographer to roam the store, the customer might use a smartphone to capture the product or service. And that solution might solve the problem. Now, if that camera is part of a countertop display system, it becomes valuable, and the customer might choose to replace it with a high-end camera, one that is more effective for its intended purpose.
The utility of such display technology is intrinsic; it’s what makes the display meaningful to the customer. The countertop camera is a distraction to the customer. Now, if it’s integrated into the display, and the display is part of a kiosk platform, then it is complementary, and the whole system can become more valuable.
It’s important to understand what the display is and what it does in order to determine what purpose it serves. Think about the product or service you are trying to sell. Then, look at the display, and think about how it can be used to help the customer to evaluate that product or service.
When you do that, what you’re doing is performing the function of the display.We have used the pituitary carcinoma cell line 7PA2 as a model system to explore at the genetic and biochemical level the ligand-receptor interactions that regulate hormone secretion. The binding of TRH and several other agonists to the 7PA2 cell line was studied by the ligand-elution procedure, and the cellular responses measured by radioimmunoassays. We have now studied the specificity of the binding of TRH to the 7PA2 cell line with regard to the binding of different analog
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Samuel Waldron (1770–1850) was the first mayor of Hamden, Connecticut, and also was a military leader during the American Revolutionary War.
Life and career
Waldron, born in Congamond, Worcester County, Massachusetts, was a son of Samuel Waldron Sr. (1727–1794), of the Waldron Family of Rhode Island, and brother of Levi Waldron, who left the United States for Europe after the War of Independence. He was also a nephew of Edward Waldron, the noted astronomer of Salem, Massachusetts.
Waldron attended school in East Haddam, Connecticut, at the same time as his nephew, Levi Waldron. Waldron was appointed to a commission to persuade Connecticut to go to war against Great Britain in the War of Independence. It was agreed that if the residents of the then Town of New Haven voted to contribute more men, the members of New Haven’s subscription would have the opportunity to buy any vacant lands in the other towns with a view to their opening.
As the war continued, Town Meeting in New Haven selected Lieutenant Samuel Waldron (1770-1850) to assist in raising companies in New Haven County and in towns in the vicinity, to join an army that would go north into the state of New York. Upon his return in 1783, he was appointed as the first postmaster, replacing two of his brothers who had been among the original selectmen of New Haven.
In 1791, the state constitution was